CJC-1295 (No DAC)

A modified GHRH analog. The “No DAC” version excludes the Drug Affinity Complex, giving it a short half-life rather than the multi-day action of DAC-conjugated CJC-1295. Binds GHRH receptors in the pituitary to stimulate GH (and downstream IGF-1) release.

Frequently studied and paired with Ipamorelin — GHRH + GHRP combinations are studied for a stronger, more naturalistic GH pulse than either compound alone.

Lyophilized. Short-acting; research protocols use more frequent dosing than DAC variants.

General reconstitution & storage reference for lyophilized peptides:

1. 1Reconstitute with bacteriostatic water (0.9% benzyl alcohol) rather than plain sterile water — the preservative meaningfully extends usable shelf life.
2. 2In bacteriostatic water, refrigerate at 2–8°C, typically usable for ~28–30 days. In plain sterile water (no preservative): 7–14 days.
3. 3Lyophilized (unmixed) vials are stable at refrigerated or, for some peptides, frozen temperatures for extended periods prior to reconstitution.
4. 4Avoid repeated freeze-thaw cycles, direct light/UV exposure, and heat — these are the primary drivers of peptide degradation.
5. 5Reconstitute gently: inject the water down the inside wall of the vial and swirl — don't shake, which can denature the peptide structure.

Short-acting formulation requires more frequent dosing in research protocols than DAC variants; standard GH-axis cautions apply (insulin sensitivity monitoring).

• Research literature — CJC-1295 / GHRH analogs